Unlocking dislocation secrets

Unlocking the secrets of longevity genes.

Unlocking Family Secrets K+ Channel Transmembrane Domains

a cloud of cations, effectively concentrating them above the level of surrounding anions. When the channel opens, hydrated cations rapidly accelerate by electrodif-and Children's Hospital fusion into an 18 A ˚ –long hydrophobic canal that leads into a wider, 10 A ˚ –long cavity. In this cavity, dozens of Boston, Massachusetts 02115 H 2 O molecules are attracted to the K ϩ ion to help shield its...

Micropuncture: unlocking the secrets of renal function.

This essay looks at the historical significance of five APS classic papers that are freely available online: Wearn JT and Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in the renal tubules. Am J Physiol 71: 209-227, 1924 (http://ajplegacy.physiology.org/cgi/reprint/71/1/209). Richards AN and Walker AM. Methods of colle...

Unlocking the secrets of cell signaling.

My scientific life has been spent trying to understand how cells communicate with each other. This interest in cell signaling began with studies on the control of fluid secretion by an insect salivary gland, and the subsequent quest led to the discovery of inositol trisphosphate (IP3) and its role in calcium signaling, which effectively divided my scientific career into two distinct parts. The ...

Learning Assigned Secrets for Unlocking Mobile Devices

Nearly all smartphones and tablets support unlocking with a short user-chosen secret: e.g., a numeric PIN or a pattern. To address users’ tendency to choose guessable PINs and patterns, we compare two approaches for helping users learn assigned random secrets. In one approach, built on our prior work [16], we assign users a second numeric PIN and, during each login, we require them to enter it ...